Olanzapine (OLAN) as an antipsychotic agent has shown its potential in effective management of psychotic disorders however its use is limited because of its poor water solubility. The aim of present work was to improve solubility of OLAN by developing a stable nanocrystal based orally disintegrating tablets (ODTs), using hyperomellose as potential stabilizer. Comparative evaluation of electrospraying and lyophilization as solidification techniques was carried out to assess its effect on solid state properties of OLAN nanocrystals before transformation to ODTs. OLAN Nanosuspension was developed using antisolvent precipitation method and exhibited particle size, polydispersity index and zetapotential value of 223.1 +/- 1.5 nm, 0.105 +/- 0.4 and -17.9 +/- 3.5 mV respectively. Solid powders obtained from both the solidification techniques were compared in terms of size after re-dispersion, particle morphology, surface area, pore volume and solid state of drug present. Subsequently ODTs were prepared from these powders with needful excipients and % amount dissolved was evaluated. Rate of dispersion was found to be higher for ODTs prepared using lyophilized powder (similar to 84% in 5 min) while other characterization parameters were comparatively similar. Overall, Lyophilization resulted in powders with better bulk level properties in comparison to electrospraying process. (C) 2018 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.