Precipitation of calcium carbonate is a common phenomenon in nature, which has attracted attention from researchers due to its importance in biomineralization processes, climatic changes, and especially incrustations in pipelines. In this work, a two-fluid model is proposed for homogeneous crystallization of calcium carbonate in highly supersaturated solutions. By making an analogy between the dynamics of a granular gas and the dynamics of a solid dispersion, the proposed model not only accounts for the interaction forces between the solid particles and dispersion medium, but also for the mass transfer and changes in the particles size during the precipitation reaction. Moreover, by using a numerical scheme based on an iterative algorithm, 3D numerical simulations are performed for the homogeneous crystallization of calcium carbonate, and the results are compared with experimental particles size distributions and curves of pH versus time. The good agreement between theoretical and experimental results indicates that the two-fluid model can be successfully used to evaluate the growth kinetics of calcium carbonate nuclei. (C) 2018 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.