For separation of the mixtures cyclohexanone with alcohols by distillation, the isobaric vapor liquid equilibrium data for cyclohexanone + (ethanol/n-propanol/isopropanol) were measured at 101.3 kPa. The van Ness, pure component consistency, and Herington test were used to validate the measured data consistency. The measured data were fitted by the Wilson, NRTL, and UNIQUAC models with the optimized binary parameters. For comparison, the phase equilibrium values for the investigated mixtures were predicted by the COSMO-SAC and UNIFAC models, and the standard deviations of vapor phase composition by the two models are less than 0.0043 and 0.0055.