Thermodynamic properties of L-Alanine and L-Valine in aqueous solutions of drug dolonex, have been investigated by combination of volumetric and acoustic methods at various temperatures (293.15, 298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The experimental data is further used to calculate limiting apparent molar volume, V-Phi o, limiting apparent molar volume of transfer, V-Phi,V-tro, limiting molar isentropic compression, K-Phi,S(o) and limiting apparent molar isentropic compression of transfer, K-Phi,S,tr(o) . Furthermore, apparent molar expansivity, E-Phi o, Hepler constant values, (partial derivative E-Phi(o)/partial derivative T)(p), coefficient of thermal expansion, alpha and hydration number, n(H) were also calculated. The obtained results were used to interpret solute-solute and solute-solvent interactions in these systems. The volumetric and compressibility data suggests dominance of hydrophilic-hydrophilic interactions in these systems. (C) 2018 Elsevier Ltd.