We report a sensitive non-steroidal anti-inflammatory drug aspirin (ASA) sensor studies using the nitrogen-doped carbon quantum dots (N-CQD) decorated copper oxide (Cu(2)0). A simplistic approach of electrochemical deposition method has been used to prepare the N-CQD incorporated with copper oxide (N-CQD/Cu(2)0) and the resulting composite has characterized by analytical techniques. Modified glassy carbon electrode of N-CQD/Cu(2)0/GCE is developed and is used for the sensor studies of aspirin. The modified N-CQD/Cu(2)0/GCE has exhibited a higher current (l(pa)) response to the oxidation process when compared to N-CQD/GCE, Cu(2)0/GCE and bare GCE. Furthermore, it has shown a good linear range of 1-907 mu M with a limit of detection (LOD) similar to 0.002 mu M and sensitivity similar to 21.87 mu A mu M-1 cm(-2). The developed sensor has displayed outstanding repeatability, stability and accumulation time along with better electro-catalytic response in berries for real-life application. (C) 2018 Elsevier Inc. All rights reserved.