Macroion-droplet interactions play a critical role in many settings such as ionization techniques of samples in mass spectrometry analysis and atmospheric aerosols. The droplets under investigation are composed of a polar solvent, primarily water, a charged macroion, and, possibly, buffer ions. We present highlights of our research on the relation between the charge state of a macroion and the droplet morphologies. We have determined that, depending on the charge on the macroion and certain macroscopic properties of the solvent, such as its dielectric constant and surface tension, a droplet may obtain striking conformations such as droplets with extruded tails, "pearl-necklace" conformations, and multipoint "star" shapes. The shapes of the droplet containing the macroion influence the charging mechanism of the macroion in a reciprocal manner. Understanding of the macroion-droplet interactions plays a central role in explaining the origin and the magnitude of the charge in spectra obtained in electrospray ionization mass spectrometry experiments and in controlling the stability of complexes of nucleic acids and proteins in droplets.