Stimuli-responsive hydrogels have been considered to have various applications in numerous fields. In the present work, a double-network (DN) hydrogel has been synthesized. The copolymers of 2-acrylamide-2-methylpropane sulfonic acid (AMPS) and acrylamide (AM) [P(AMPS-co-AM)] are prepared as the 1st network and poly(acrylic acid) as the 2nd network. This DN hydrogel is sensitive to glucose by introducing the glucose-sensitive group phenylboronic acid to the network. The tribological properties of this glucose-sensitive DN hydrogel have been investigated using a universal mechanical tester (UMT-5). The tribological results show that the friction coefficient varied with the glucose solution. The friction coefficient increased to a maximum of 0.06, and finally decreased to 0.025 with the increase in the glucose concentration. An adjustable friction coefficient of the hydrogel, between 0.025 and 0.056, was achieved along with the change of lubricant. According to the tribological experimental results and the analysis of the DN structure, it can be deduced that a hydrated layer exists in the interface of the hydrogel. The hydrated layers consisting of water molecules are bounded with the hydrophilic group of the hydrogel network by hydrogen bonds. The change in the number of water molecules leads to the difference in the water content of the hydrogel, which further resulted in the various tribological properties. In addition, the hydrogel's mesh size also has an impact on the change in friction coefficient. In general, the adjustable friction of the hydrogel in a glucose environment is achieved.