Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal filler for anti-ageing treatment

Jia Nan Zhang; Bo Zhi Chen; Mohammad Ashfaq; Xiao Peng Zhang; Xin Dong Guo

Journal of Industrial and Engineering Chemistry, Vol.65, 363-369, September, 2018

DOI10.1016/j.jiec.2018.05.007 Export Citation

Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal filler for anti-ageing treatment

Jia Nan Zhang, Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, and Xin Dong Guo^†

Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China

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Hyaluronic acid (HA) has many applications in human medicine and cosmetic industry. This study describes the fabrication and evaluation of cross-linked HA (cHA) based microneedles (HA-cHA-MNs) for anti-ageing treatment. The results suggested that the increasing content of cHA gel particles decrease the mechanical properties of MNs. The in-vitro degradation profile and in-vivo epidermal expansion in mice were also carried out. The data suggested that the proportion of cHA particles decreased the rate of MNs degradation. The prepared HA-cHA-MNs have prolonged effectiveness with high swelling retention time or epidermal expansion time in mice up to 6 days or more.

Keywords:Hyaluronic acid;Microneedle;Cosmetic;Anti-ageing;Skin

[References]

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Sadri A, Nassab R, Plast J, Reconstr. Aesthet. Surg., 68, 269 (2015)
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Park Y, Park J, Chu GS, Kim KS, Sung JH, Kim B, Biotechnol. Bioproc. Eng., 20, 543 (2015)
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Edsman K, Nord LI, Ohrlund A, Larkner H, Kenne AH, Dermatol. Surg., 38, 1170 (2012)
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[Referenced By]

[1] Kim JE, Sykes JM, Facial Plast. Surg., 27, 523 (2011)

[2] Goulian D, Aesthet. Plast. Surg., 2, 247 (1978)

[3] Matton G, Anseeuw A, De Keyser F, Aesthet. Plast. Surg., 9, 133 (1985)

[4] Sadri A, Nassab R, Plast J, Reconstr. Aesthet. Surg., 68, 269 (2015)

[5] Andre P, J. Cosmet. Dermatol., 7, 251 (2008)

[6] Klein AW, Dermatol. Ther., 19, 129 (2006)

[7] Flynn TC, Thompson DH, Hyun SH, Plast. Reconstr. Surg., 132, 22S (2013)

[8] O'Reilly P, Malhotra R, Orbit, 30, 54 (2011)

[9] Zamani M, Thyagarajan S, Olver JM, Ophthal. Plast. Reconstr. Surg., 26, 250 (2010)

[10] Wu Y, Sun N, Xu Y, Liu H, Zhong S, Chen L, et al., Arch. Dermatol. Res., 308, 145 (2016)

[11] Battula N, Menezes V, Hosseini H, Biotechnol. Bioeng., 113(11), 2507 (2016)

[12] Subramony JA, Int. J. Pharm., 455, 14 (2013)

[13] Park Y, Kim KS, Chung M, Sung JH, Kim B, J. Ind. Eng. Chem., 39, 121 (2016)

[14] Kim M, Yang H, Kim H, Jung H, Jung H, Int. J. Cosmetic Sci., 36, 207 (2014)

[15] Picotti F, Fabbian M, Gianni R, Sechi A, Stucchi L, Bosco M, Carbohydr. Polym., 93, 273 (2013)

[16] Dicker KT, Gurski LA, Pradhan-Bhatt S, Witt RL, Farach-Carson MC, Jia X, Acta Biomater., 10, 1558 (2014)

[17] Zawko SA, Suri S, Truong Q, Schmidt CE, Acta Biomater., 5, 14 (2009)

[18] Juhlin L, J. Intern. Med., 242, 61 (1997)

[19] Salwowska NM, Bebenek KA, Zadlo DA, Wcislo-Dziadecka DL, J. Cosmet. Dermatol., 15, 520 (2016)

[20] Tezel A, Fredrickson GH, J. Cosmet. Laser. Ther., 10, 35 (2008)

[21] Maclennan AP, J. Gen. Microbiol., 14, 134 (1956)

[22] Prehm P, Biochem. J., 267, 185 (1990)

[23] Kogan G, Soltes L, Stern R, Gemeiner P, Biotechnol. Lett., 29(1), 17 (2007)

[24] Park Y, Park J, Chu GS, Kim KS, Sung JH, Kim B, Biotechnol. Bioproc. Eng., 20, 543 (2015)

[25] De Boulle K, Glogau R, Kono T, Nathan M, Tezel A, Roca-Martinez JX, et al., Dermatol. Surg., 39, 1758 (2013)

[26] Al-Sibani M, Al-Harrasi A, Neubert RH, Eur. J. Pharm. Sci., 91, 131 (2016)

[27] Yang B, Guo X, Zang H, Liu J, Carbohydr. Polym., 131, 233 (2015)

[28] Wang QL, Zhu DD, Chen Y, Guo XD, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 65, 135 (2016)

[29] Chen Y, Chen BZ, Wang QL, Jin X, Guo XD, J. Control. Release, 265, 14 (2017)

[30] Edsman K, Nord LI, Ohrlund A, Larkner H, Kenne AH, Dermatol. Surg., 38, 1170 (2012)

[31] Becker LC, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC, et al., Int. J. Toxicol., 28, 5 (2009)

[32] Kim M, Jung B, Park JH, Biomaterials, 33, 668 (2012)