Mixed-matrix membranes (MMMs) have shown great advantages but still face some challenges, such as the trade-off between permeability and selectivity, stability, and the lack of efficient ways to enhance them simultaneously. Here, the fabrication of MMMs with metal-organic frameworks derived porous carbons (MOF-PCs) as fillers which exhibit selective-facilitating CO2 transport passage originating from interactions between fillers and CO2 is showed. With the aid of the developed multicalcination method, MOF-PCs with variable N-contents were prepared and incorporated into PPO-PEG matrix for the first time to prepare MMMs, which show excellent separation performance for CO2/CH4 mixture with a tunable separation performance by combining different N-contents and surface areas of MOF-PCs. Moreover, the developed MMMs have hydrothermal and chemical stability. This work not only presents a series of MMMs with both good separation properties and stability, it also provides useful information for guiding the fabrication of high performance MMMs for practical application. (c) 2018 American Institute of Chemical Engineers AIChE J, 64: 3400-3409, 2018