The study investigates the comprehensive effects of superheat and internal heat exchanger (IHX) on the thermo-economic performance of organic Rankine cycle (ORC). Exergy efficiency, net power output, and electricity production cost (EPC) are compared based on the working fluid properties and heat sources. The results indicate that under a lower heat source temperature and load, exergy efficiency of IHX-ORC does not always exceed that of simple ORC (S-ORC) when EPC is selected as an objective function, and IHX-ORC exhibits a worse economic performance than S-ORC for all fluids (R161, R1234ze, R152a, cyclopropane, butane, 8123, cyclopentane, heptane, and cyclohexane). However, IHX-ORC with dry fluid achieves a better thermo-economic performance than that with wet fluid when the heat source temperature and load increase to a high level. The EPC of IHX-ORC is close to that of S-ORC with the increase in heat source temperature and load, and thus, IHX-ORC exhibits approximately 10-17% higher thermal efficiency and 5-10% higher exergy efficiency than those of S-ORC. With respect to butane and R123, the net power output exhibits approximately 22.5% and 23.5% growth, respectively. In order to evaluate the feasibility of IHX-ORC, a judgement indicator [alpha > 1.90625 + 0.4258 xi] with respect to six factors is proposed. (C) 2018 Elsevier Ltd. All rights reserved.