Rational design of highly active, stable, and inexpensive catalysts with abundant interfaces can have great potential to increase catalytic performance. Topological transformation of layered double hydroxides (LDHs) to the corresponding mixed metal oxides (MMOs) offers an efficient strategy to achieve such interfaces. However, the formation and conversion of these heterostructured interfaces is lacking in study and remains elusive. Herein, we report a detailed investigation of the topological transformation of LDHs. The as-prepared MMO with abundant interfaces can be modulated by calcination of ZnCo-LDH at different temperatures. Among them, the ZnCo-LDH calcinated at 200 degrees C reveals the most abundant interfaces and exhibits excellent performance in electrochemical water oxidation. This work will deepen the understanding of the LDH topological transformation from the molecular level.