The establishment of novel design strategies to target chiral rodlike MOFs, elusively faced until now, is one of the most straightforward manners to widen the scope of MOFs. Here we describe our last advances on the application of the metalloligand design strategy toward the development of efficient routes to obtain chiral rodlike MOFs. To this end, we have used as precursor an enantiopure homochiral hexanuclear wheel (1), derived from the amino acid D-valine, which, after a supramolecular reorganization into a one-dimensional homochiral chain-with the same configuration as 1-led to the formation of a homochiral rodlike MOF (2) exhibiting rare etd topology.