In this work, a techno-economic analysis of a hydrogen production plant based on the Ca-Cu process has been carried out. The simulation of the whole hydrogen production plant has been performed, including the calculation of the Ca-Cu fixed bed reactors system using a sharp front modelling approach. From the analyses carried out, it has been demonstrated that the optimal operation point from the energy performance point of view is reached when fuel needed for sorbent regeneration is entirely supplied by the off-gas from the PSA hydrogen purification unit, which corresponds to operating the plant with the minimum steam-to-carbon ratio in the reforming step. Moreover, lowering the operating pressure of the Ca-Cu system results beneficial from the hydrogen production efficiency, but the CO2 emissions and the economics worsen. The Ca-Cu based hydrogen production plant operating at a high pressure has been demonstrated to be cost efficient with respect to a benchmark hydrogen production plant based on conventional fired tubular reformer and CO2 capture by MDEA absorption. A hydrogen production cost of 0.178 (sic)/Nm(3) and a CO2 avoided cost of 30.96 (sic)/ton have been calculated for this Ca-Cu hydrogen production plant, which are respectively 8% and 52% lower than the corresponding costs of the benchmark. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.