The equilibrium solubility of 4-amino-2,6-dimethoxypyrimidine in different kinds of binary mixed solvents-methanol + water (283.15-323.15 K), ethanol + water (283.15-323.15 K), isopropanol + water (283.15-323.15 K), and DMF + water (283.15-323.15 K)-was measured by a dissolution equilibrium technique under p = 101.1 kPa. The experimental value of 4-amino-2,6-dimethoxypyrimidine solubility has a certain functional relationship with temperature and the mass fraction of methanol (ethanol, isopropanol, and DMF). Within all mass fractions of organic solvents and temperature, the 4-amino-2,6-dimethoxypyrimidine was more soluble in the DMF + water system than in the other three binary systems. Besides, the solubility of 4-amino-2,6-dimethoxypyrimidine was calculated by three different thermodynamic models, including the Apelblat-Jouyban-Acree model, the Jouyban-Acree model, and the van't Hoff-Jouyban-Acree model, to obtain the maximum value of RAD (average relative deviations) of 3.29%, which fully verified the accuracy of the experimental data.