Equilibrium solubilities of chloroxine in binary solvent mixtures of ethyl acetate plus methanol, ethanol, n-propanol, and isopropanol were measured by the static equilibrium method in the temperature range of 283.15-333.15 K at pressure of 1 atm. The solubility data is positively increased with increasing temperature at different solvent composition ranging from 0 to 1 and decreased with the increasing mass fraction of alcohol in each binary system, and the maximum solubility of 7.819 X 10(-3) at 333.15 K was found in neat ethyl acetate. Under the same composition of ethyl acetate and temperature conditions, the solubility of chloroxine was greater in (methanol + ethyl acetate) than in the other three solution mixtures. Several mathematical models, that is, the Jouyban-Acree model, Van't Hoff-Jouyban-Acree model and Apelblat-Jouyban-Acree model were adopted to correlate the measured solubility values. As a result, the calculated data are in alignment to measured values at evaluated temperatures and RAD (X 10(-2)) and RMSD (X 10(-4)) data were no more than 3.49 and 0.94, respectively. X-ray powder diffraction serves to analyze the equilibrium solid phase crystal of chloroxine and results turns out that no polymorphic transformation, solvate formation or crystal transition in the whole solvent crystallization process.