Liquid-liquid equilibrium (LLE) data was very important for the process design and optimization of 5-hydroxymethylfurfural (5-HMF) production. To provide this fundamental data, experimental liquid liquid equilibrium data for ternary systems, {water + 5-HMF + 1-butanol}, {water + 5-HMF + isobutanol}, and {water + 5-HMF + methyl isobutyl ketone}, were measured at 313.15, 323.15, and 333.15 K. Partition coefficients were used to assess the extraction capacity of organic solvents in the biphasic systems. 1-Butanol and isobutanol were desirable extractants with good extraction performance and environmental benign properties. The NRTL model was used to correlate the experimental data and the binary interaction parameters were obtained. The average relative deviation was lower than 10%.