Persulfate is the latest oxidant which is being used increasingly for the remediation of groundwater and soil contaminated with organic compounds. It is of great significant to offer readers a general summary about different methods of activating persulfate, mainly including heat-activated, metal ions-activated, UV-activated, and alkaline-activated. Meanwhile, in addition to persulfate concentration as an influencing factor for persulfate oxidation process, selected information like temperature, anions, cations, pH, and humic acid are presented and discussed. The last section focuses on the advantages of different activated persulfate processes, and the suggestions and research needs for persulfate-based advanced oxidation in the remediation of polluted groundwater and soil.