To achieve efficient degradation of toluene, a series of Cu1-yMn2CeyOx/sepiolite catalysts (y = 0.1, 0.2, and 0.3) with different Cu1-yMn2CeyOx loadings (10%, 20%, and 30%) were prepared via the co-precipitation method. The structure-activity and surficial elemental species of Cu1-yMn2CeyOx/sepiolite were characterized by XRD, TEM, SEM, BET, ICP-MS and XPS. The catalytic activity of the catalysts was tested in the oxidation reaction of toluene, results showed that 20%Cu0.8Mn2Ce0.2Ox/sepiolite remains able to remove toluene completely with high efficiency at a temperature of 289 degrees C. Two kinetic models have been selected and tested to describe the oxidation of toluene, the Mars-van krevele (MVK) model provided a good fit (R-2 >= 0.99). And the optimal relation of the surface oxidation activation energy (26.074 kJ mol(-1)) and surface reduction activation energy (23.591 kJ mol(-1)) were calculated.