An amorphous ultra-dispersed electrocatalyst, AU-Pt/PMC, is successfully synthesized via severe etching process for glycerol oxidation reaction. What's appealing, it presents amorphous structure with ultra-small Pt clusters (0.36 nm) anchoring on nitrogen functionalized carbon support. Notably, the AU-Pt/PMC electrocatalyst takes on 5.1 times the activity and 24.3 times the stability compared with commercial Pt/C for glycerol oxidation reaction. The impressive electrocatalytic performance originates from the unique amorphous ultra-dispersed structure, as well as the superimposed effect between Pt clusters and Strong Metal-Support Interactions.