With modern industrial processes becoming larger and more complex, we should consider their nonlinear and multimode characteristics carefully for accurate process monitoring and fault detection. In this paper, a novel hybrid of two data-driven techniques-auto-associative kernel regression (AAKR) and dynamic independent component analysis (DICA)-is proposed for fault detection of nonlinear multimode processes. AAKR is a nonparametric multivariate technique; it can effectively deal with nonlinearity and multimodality of target systems by real-time local modeling in accordance with query vectors. Residuals obtained from AAKR usually deviate from Gaussian distribution (i.e., they are non-Gaussian), and there exist auto- and cross-correlations between them. The proposed method detects process faults by applying DICA to the residuals; DICA can capture useful statistical information hidden in the residuals. The validity and effectiveness of the proposed method are illustrated through three popular benchmark problems such as a three-variable multimodal process, a three-variable nonlinear process, and Tennessee Eastman process; the proposed method is also compared with several comparison methods The experimental results demonstrate the superiority of the proposed method, which achieves the best detection rates with reasonable false alarm rates. (C) 2018 Elsevier Ltd. All rights reserved.