Single-entity electrochemistry (SEE) describes a recent trend in state-of-the-art electrochemistry applied to the study of individual "things." Conceptually, SEE covers fundamentals and applications of SEE, as well as methods and tools to make SEE measurements. SEE is especially appealing, as it unifies different branches of electrochemistry and comingles diverse approaches and techniques toward similar goals. In this Perspective, motivations and advantages of SEE are considered. A brief historical perspective and overview of recent ideas and directions in research in SEE are considered. In closing, future challenges, opportunities, and destinations related to SEE are discussed.