화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.140, No.40, 12705-12709, 2018
Diastereoselective Allylation of Aldehydes by Dual Photoredox and Chromium Catalysis
Herein, we report the redox-neutral allylation of aldehydes with readily available electron-rich allyl (hetero-) arenes, beta-alkyl styrenes and allyl-diarylamines. This process was enabled by the combination of photoredox and chromium catalysis, which allowed a range of homoallylic alcohols to be prepared with high levels of selectivity for the anti diastereomer. Mechanistic investigations support the formation of an allyl chromium intermediate from allylic C(sp(3))-H bonds and thus significantly extends the scope of the venerable Nozaki-Hiyama-Kishi reaction.