This paper presents robust PID tuning for the Smith predictor in the presence of model uncertainty. The concept of the equivalent gain plus time delay (EGPTD) is introduced to incorporate robust stability in PID tuning of the Smith predictor. In particular, an application is developed for the robust tuning of the first order plus time delay (FOPTD) system and the second order plus time delay (SOPTD) system because the systems have been used extensively to describe chemical processes. The proposed tuning method can cope with simultaneous uncertainties in all parameters of the model in an efficient manner. Another important and attractive feature of the method is that it can utilize many currently available PID tuning rules. Simulation results are provided to demonstrate the availability of the method.