The microbial fuel cells (MFC) can directly transform chemical energy in feed substance to electricity by anodic aspiration pathways. This mini review provides an order-of-magnitude argument that MFC has much lower catalyst density at electrode surface and much higher diffusional resistance for substrates than the chemical fuel cell, the former should not be used as an energy generation unit; rather, it should be applied in low power density level applications such as biofilm wastewater treatment. The literature studies using MFC for pollution treatment are discussed. (C) 2017 Elsevier Ltd. All rights reserved.