화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.26, No.12, 1085-1094, December, 2018
DOI10.1007/s13233-018-6151-8  Export Citation
DNA-Coated Microspheres and Their Colloidal Superstructures
Jeongbin Moon1, In-Seong Jo1, Etienne Ducrot2, Joon Suk Oh2, David J Pine2, 3, and Gi-Ra Yi1, †
  • 1Department of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea
  • 2Center for Soft Matter Research and Department of Physics, New York University, New York, NY 10003, USA
  • 3Department of Chemical and Biomolecular Engineering, New York University, Brooklyn, NY, 11201, USA
E-mail:
Reversible and specific interaction between single-stranded DNA on colloidal particles have opened up a new path way of building up colloidal superstructures. DNA-coated microspheres can be bound with other particles with complementary DNA brushes below the melting temperature and can be unbound above the melting temperature. However, due to their random Brownian motion, the particles form random (or glassy) structures in most cases or small crystals when cooling is extremely slow. Therefore, toward programmed colloidal superstructures of DNA-coated microspheres, they should reconfigure their kinetically trapped random structure to equilibrium crystalline structures. While nanoparticles can be rearranged into a crystalline structure by a simple conformational change of relatively long DNA brush, microspheres with short DNA brushes cannot be rearranged only by a conformational change of brush. Instead, sub-diffusion of bound DNA-coated microspheres is necessary which can be possible only with uniform DNA coating with high areal density on microspheres. In this article, we have reviewed methods for the synthesis of high-density DNA-coated microspheres and their assembly into crystalline structures. We also discuss future research direction of DNA-coated microspheres.
Keywords:DNA coating;microsphere;self-assembly;DNA hybridization;sub-diffusion;crystallization
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