Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model

Jin Kim; Chang-Moon Lee

Macromolecular Research, Vol.26, No.13, 1219-1224, December, 2018

DOI10.1007/s13233-019-7014-7 Export Citation

Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model

Jin Kim^{1, 2}, and Chang-Moon Lee^{3, 2, †}

¹Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 61186, Korea
²Research Center of Healthcare Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea
³Department of Biomedical Engineering, Chonnam National University, Yeosu 59626, Korea

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The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccharide in RAW264.7 cells with a concentration-dependent manner. Wounds were prepared through excision to remove full-thickness skin of rats k]and then were covered with CHP. The covered wounds showed significantly rapid contraction and closure. Histological tissue examination indicated that CHP induced advanced granulation tissue formation and re-epithelialization in the wound. These results indicate that CHP may be helpful for the promotion of wound healing.

Keywords:propolis;hydrogel;wound healing;carbopol;polyacrylic acid;transdermal gel

[References]

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Fratini F, Cilia G, Mancini S, Felicioli A, Microbiol. Res., 192, 130 (2016)
Huang S, Zhang CP, Wang K, Li GQ, Hu FL, Molecules, 19, 19610 (2014)
McLennan SV, Bonner J, Milne S, Lo L, Charlton A, Kurup S, Jia J, Yue DK, Twigg SM, Wound Repair Regen., 16, 706 (2008)
Pillai SI, Palsamy P, Subramanian S, Kandaswamy M, Pharm. Biol., 48, 1198 (2010)
Eming SA, Krieg T, Davidson JM, J. Invest. Dermatol., 127, 514 (2007)
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Chan CGF, Cheung KW, Sze DMY, Clinc. Rev. Allerg. Immunol., 44, 262 (2013)
Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A, Int. J. Mol. Sci., 17, 160 (2016)
Kadajji VG, Betageri GV, Polymers, 3, 1972 (2011)
Chirani N, Yahia L, Gritsch L, Motta FL, Chirani S, Fare S, J. Biomed. Sci., 4, 1 (2015)
A-sasutjarit R, Sirivat A, Vayumhasuwan P, Pharm. Res., 22, 2134 (2005)
Kaler A, Mittal AK, Katariya M, Harde H, Agrawal AK, Jain S, Banerjee UC, J. Nanopart. Res., 16, 2605 (2014)
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Chang CC, Yang MH, Wen HM, Chern JC, J. Food Drug Anal., 10, 178 (2002)
Ozturk M, Aydogmus-Ozturk F, Duru ME, Topcu G, Food Chem., 103, 623 (2007)
Granger DL, Tanintor RR, Boockvar KS, Hibbs JB, Methods Enzymol., 268, 142 (1996)
Kahkonen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Jujala TS, Heinonen M, J. Agric. Food Chem., 47, 3954 (1999)
Aksoy L, Kolay E, Agilonu Y, Aslan Z, Kargioglu M, Saudi J. Biol. Sci., 20, 235 (2013)
Lu LC, Chen YW, Chou CC, Int. J. Food Microbiol., 102, 213 (2005)
Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M, Microbiol. Res., 158, 353 (2003)
Song YS, Park EH, Hur GM, Ryu YS, Kim YM, Jin C, J. Ethnopharmacol., 80, 155 (2002)
Paulino N, Teixeira C, Martins R, Scremin A, Ddirsch VM, Vollmar AM, Abreu SR, de Castro SL, Marcucci MC, Planta Med., 72, 899 (2006)
Pasupuleti VR, Sammugam L, Ramesh N, Gan SH, Oxid. Med. Cell. Longev., 2017, 1 (2017)
Gharibi R, Yeganeh H, Rezapour-Lactoee A, Hassan ZM, ACS Appl. Mater. Interfaces, 7, 24296 (2015)
Kim SJ, Lim MH, Chun IK, Won YH, Skin Pharmacol., 10, 200 (1997)

[Referenced By]

[1] Silva-Carvalho R, Baltazar F, Almeida-Aguiar C, Evid. Based Complement. Alternat. Med., 2015, 206439 (2015)

[2] Fratini F, Cilia G, Mancini S, Felicioli A, Microbiol. Res., 192, 130 (2016)

[3] Huang S, Zhang CP, Wang K, Li GQ, Hu FL, Molecules, 19, 19610 (2014)

[4] McLennan SV, Bonner J, Milne S, Lo L, Charlton A, Kurup S, Jia J, Yue DK, Twigg SM, Wound Repair Regen., 16, 706 (2008)

[5] Pillai SI, Palsamy P, Subramanian S, Kandaswamy M, Pharm. Biol., 48, 1198 (2010)

[6] Eming SA, Krieg T, Davidson JM, J. Invest. Dermatol., 127, 514 (2007)

[7] Daleprane JB, Abdalla DS, Evid. Based Complement. Alternat. Med., 2013, 175135 (2013)

[8] Chan CGF, Cheung KW, Sze DMY, Clinc. Rev. Allerg. Immunol., 44, 262 (2013)

[9] Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A, Int. J. Mol. Sci., 17, 160 (2016)

[10] Kadajji VG, Betageri GV, Polymers, 3, 1972 (2011)

[11] Chirani N, Yahia L, Gritsch L, Motta FL, Chirani S, Fare S, J. Biomed. Sci., 4, 1 (2015)

[12] A-sasutjarit R, Sirivat A, Vayumhasuwan P, Pharm. Res., 22, 2134 (2005)

[13] Kaler A, Mittal AK, Katariya M, Harde H, Agrawal AK, Jain S, Banerjee UC, J. Nanopart. Res., 16, 2605 (2014)

[14] Asami DK, Hong YJ, Barrett DM, Mitchell AE, J. Agric. Food Chem., 51, 1237 (2003)

[15] Chang CC, Yang MH, Wen HM, Chern JC, J. Food Drug Anal., 10, 178 (2002)

[16] Ozturk M, Aydogmus-Ozturk F, Duru ME, Topcu G, Food Chem., 103, 623 (2007)

[17] Granger DL, Tanintor RR, Boockvar KS, Hibbs JB, Methods Enzymol., 268, 142 (1996)

[18] Kahkonen MP, Hopia AI, Vuorela HJ, Rauha JP, Pihlaja K, Jujala TS, Heinonen M, J. Agric. Food Chem., 47, 3954 (1999)

[19] Aksoy L, Kolay E, Agilonu Y, Aslan Z, Kargioglu M, Saudi J. Biol. Sci., 20, 235 (2013)

[20] Lu LC, Chen YW, Chou CC, Int. J. Food Microbiol., 102, 213 (2005)

[21] Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M, Microbiol. Res., 158, 353 (2003)

[22] Song YS, Park EH, Hur GM, Ryu YS, Kim YM, Jin C, J. Ethnopharmacol., 80, 155 (2002)

[23] Paulino N, Teixeira C, Martins R, Scremin A, Ddirsch VM, Vollmar AM, Abreu SR, de Castro SL, Marcucci MC, Planta Med., 72, 899 (2006)

[24] Pasupuleti VR, Sammugam L, Ramesh N, Gan SH, Oxid. Med. Cell. Longev., 2017, 1 (2017)

[25] Gharibi R, Yeganeh H, Rezapour-Lactoee A, Hassan ZM, ACS Appl. Mater. Interfaces, 7, 24296 (2015)

[26] Kim SJ, Lim MH, Chun IK, Won YH, Skin Pharmacol., 10, 200 (1997)