폐암 질환 진단에 활용 가능한 바이오마커 검출용 바이오칩 센서 연구 동향

이상혁; 고은서; 이혜진; Sang Hyuk Lee; Eunseo Goh; Hye Jin Lee

Applied Chemistry for Engineering, Vol.29, No.6, 645-651, December, 2018

DOI10.14478/ace.2018.1110 Export Citation

폐암 질환 진단에 활용 가능한 바이오마커 검출용 바이오칩 센서 연구 동향

Research Trend of Biochip Sensors for Biomarkers Specific to Diagnostics of Lung Cancer Diseases

이상혁, 고은서, 이혜진^†

경북대학교 자연과학대학 화학과 및 청정나노소재 연구소

Sang Hyuk Lee, Eunseo Goh, and Hye Jin Lee^†

Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu-city 41566, Republic of Korea

E-mail:

초록

한국인의 암 사망률 1위를 차지하는 폐암은 발견되기 전까지 별다른 증상이 없어 환자는 병을 쉽게 인지하지 못하고, 기존의 진단법 또한 초기단계에는 적용이 어렵다. 해결책으로서, 분자수준에서의 체액분석을 폐암진단에 도입하는 방안이 제시되고 있다. 이를 위한 분석기기 가운데 대표적으로는 칩 기반 바이오센서가 있으며, 이 센서의 큰 장점으로는 고가의 분석장비나 숙련된 분석인력이 없이도 현장에서의 진단이 가능하다는 점이다. 본 미니총설에서는 폐암 진단에 활용가능한 혈액 내 바이오마커와 바이오칩 센서의 연구현황을 소개하고 이들의 발전가능성에 대해 논의하고자 한다.

Lung cancer has the highest death rate of any cancer diseases in Koreans. However, patients often feel difficult to recognize their disease before facing the terminal diagnosis due to the absence of any significant symptoms. Furthermore, the clear detection of an early cancer stage is usually obscure with existing diagnostic methods. For this reason, extensive research efforts have been made on introducing a wide range of biochemical diagnostic tools for the molecular level analysis of biological fluids for lung cancer diagnoses. A chip-based biosensor, one type of the analytical devices, can be a great potential for the diagnosis, which can be used without any further expensive analytical equipments nor skilled analysts. In this mini review, we highlight recent research trends on searching biomarker candidates and bio-chip sensors for lung cancer diagnosis in addition to discussing their future aspects.

Keywords:Lung cancer disease;blood biomarker;biochip sensors;lateral flow immunoassay;electrochemical biosensor;optical biosensor

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[Referenced By]

[1] Chae YJ, Park JS, Asian Oncol. Nurs., 17, 79 (2017)

[2] Hammerschmidt S, Wirtz H, Dtsch. Arztebl. Int., 106, 809 (2009)

[3] Park BB, Hanyang Med. Rev., 34, 31 (2014)

[4] Li R, Feng F, Chen ZZ, Bai YF, Guo FF, Wu FY, Zhou G, Talanta, 140, 143 (2015)

[5] Altintas Z, Tothill I, Sens. Actuators B-Chem., 188, 988 (2013)

[6] Yeo LY, Chang HC, Chan PP, Friend JR, Small, 7, 12 (2011)

[7] Diba FS, Kim S, Lee HJ, Catal. Today, 295, 41 (2017)

[8] Miao X, Li Z, Zhu A, Feng Z, Tian J, Peng X, Biosens. Bioelectron., 83, 39 (2016)

[9] Tabrizi MA, Shamsipur M, Farzin L, Biosens. Bioelectron., 74, 764 (2015)

[10] Lu W, Tao L, Wang Y, Cao X, Ge J, Dong J, Qian W, Ionics, 21, 1141 (2014)

[11] Lim JH, Park J, Oh EH, Ko HJ, Hong S, Park TH, Adv. Healthc. Mater., 3, 360 (2014)

[12] Ho JA, Chang HC, Shih NY, Wu LC, Chang YF, Chen CC, Chou C, Anal. Chem., 82, 5944 (2010)

[13] Altintas Z, Tothill IE, Sens. Actuators B-Chem., 169, 188 (2012)

[14] Liu F, Zhang H, Wu Z, Dong H, Zhou L, Yang D, Ge Y, Jia C, Liu H, Jin Q, Zhao J, Zhang Q, Mao H, Talanta, 161, 205 (2016)

[15] Hayes B, Murphy C, Crawley A, O’Kennedy R, Diagnostics, 8, 1 (2018)

[16] Quero G, Consales M, Severino R, Vaiano P, Boniello A, Sandomenico A, et al., Biosens. Bioelectron., 80, 590 (2016)

[17] Abel AP, Weller MG, Duveneck GL, Ehrat M, Widmer HM, Anal. Chem., 68, 2905 (1996)

[18] Donzella V, Crea F, J. Biophotonics, 4, 442 (2011)

[19] Arya SK, Bhansali S, Chem. Rev., 111(11), 6783 (2011)

[20] Yang SH, J. Lung Cancer, 8, 67 (2009)

[21] Tang D, Shen Y, Wang M, Yang R, Wang Z, Sui A, Jiao W, Wang Y, Eur. J. Cancer Prev., 22, 540 (2013)

[22] Koulman A, Lane GA, Harrison SJ, Volmer DA, Anal. Bioanal. Chem., 394, 663 (2009)

[23] Shi Y, Liu X, Lou J, Han X, Zhang L, Wang Q, Li B, Dong M, Zhang Y, Clin. Cancer Res., 20, 6016 (2014)

[24] Barlesi F, Gimenez C, Torre JP, Doddoli C, Mancini J, Greillier L, Roux F, Kleisbauer JP, Respir. Med., 98, 357 (2004)

[25] Alatas F, Alatas O, Metintas M, Colak O, Harmanci E, Demir S, Lung Cancer, 31, 9 (2001)

[26] Zhou J, Nong L, Wloch M, Cantor A, Mulshine JL, Tockman MS, Lung Cancer, 34, 341 (2001)

[27] Liang Y, Ma T, Thakur A, Yu H, Gao L, Shi P, Li X, Ren H, Jia L, Zhang S, Li Z, Chen M, Glycobiology, 25, 331 (2015)

[28] Jiao C, Cui L, Ma A, Li N, Si H, PLoS One, 11, 1 (2016)

[29] Jang HR, Wark AW, Baek SH, Chung BH, Lee HJ, Anal. Chem., 86, 814 (2014)

[30] Grossi F, Loprevite M, Chiaramondia M, Ceppa P, Pera C, Ratto GB, Serrano J, Ferrara GB, Costa R, Boni L, Ardizzoni A, Eur. J. Cancer, 39, 1242 (2003)

[31] Carcereny E, Ramirez JL, Sanchez-Ronco M, Isla D, Cobo M, et al., Lung Cancer, 68, 491 (2010)

[32] Hosgood HD, Lung Cancer, 66, 157 (2009)

[33] Jang JS, Choi YY, Lee WK, Choi JE, Cha SI, Kim YJ, Kim CH, Kam S, Jung TH, Park JY, Cancer Sci., 99, 1385 (2008)

[34] Spinola M, Leoni VP, Galvan A, Korsching E, Conti B, Cancer Lett., 251, 311 (2007)

[35] Gresner P, Gromadzinska J, Jablonska E, Kaczmarski J, Wasowicz W, Lung Cancer, 65, 34 (2009)

[36] Weber DG, Johnen G, Casjens S, Bryk O, Pesch B, Jockel KH, Kollmeier J, Bruning T, BMC Res. Notes, 6, 1 (2013)

[37] Madhavan D, Cuk K, Burwinkel B, Yang R, Front. Genet., 4, 1 (2013)

[38] Kim CG, Shim HS, Hong MH, Cha YJ, Heo SJ, Park HS, Kim JH, Lee JG, Lee CY, Cho BC, Kim HR, Oncotarget, 8, 65111 (2017)

[39] Kwon MH, Lee GE, Kwon SJ, Choi E, Na MJ, Cho HM, Kim YJ, Sul HJ, Cho YJ, Son JW, Tuberc. Respir. Dis., 65, 495 (2008)

[40] Rodriguez-Enriquez S, Pacheco-Velazquez SC, Gallardo-Perez JC, Marin-Hernandez A, et al., J. Cell Biochem., 112, 2703 (2011)

[41] Zhou W, Huang PJ, Ding J, Liu J, Analyst, 139, 2627 (2014)

[42] Perfezou M, Turner A, Merkoci A, Chem. Soc. Rev., 41, 2606 (2012)

[43] Tran HV, Piro B, Reisberg S, Huy Nguyen L, Nguyen TD, Duc HT, Pham MC, Biosens. Bioelectron., 62, 25 (2014)

[44] Wang H, Wang X, Wang J, Fu W, Yao C, Sci. Rep., 6, 1 (2016)

[45] Diba FS, Kim S, Lee JH, Biosens. Bioelectron., 72, 355 (2015)

[46] Kim S, Lee HJ, Anal. Chem., 87, 7235 (2015)

[47] Kim S, Wark AW, Lee HJ, Anal. Chem., 88, 7793 (2016)

[48] Kim S, Park JW, Wark AW, Jhung SH, Lee HJ, Anal. Chem., 89, 12562 (2017)

[49] Kim S, Lee HJ, Anal. Chem., 89, 6624 (2017)

[50] Kwon MJ, Lee J, Wark AW, Lee HJ, Anal. Chem., 84, 1702 (2012)

[51] Singh T, Sharma SD, Katiyar SK, PLoS One, 6, 1 (2011)

[52] Chen Z, Liang R, Guo X, Liang J, Deng Q, Li M, An T, Liu T, Wu Y, Biosens. Bioelectron., 91, 60 (2017)

[53] Qin W, Wang K, Xiao K, Hou Y, Lu W, Xu H, Wo Y, Feng S, Cui D, Biosens. Bioelectron., 90, 508 (2017)

[54] Altintas Z, Uludag Y, Gurbuz Y, Tothill IE, Talanta, 86, 377 (2011)

[55] Wu P, Gao Y, Lu Y, Zhang H, Cai C, Analyst, 138, 6501 (2013)

[56] Homola J, Yee SS, Gauglitz G, Sens. Actuators B-Chem., 54, 3 (1999)

[57] Zeng S, Baillargeat D, Ho HP, Yong KT, Chem. Soc. Rev., 43, 3426 (2014)

[58] Li Y, Lee HJ, Corn RM, Anal. Chem., 79, 1082 (2007)