화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.71, 65-77, March, 2019
DOI10.1016/j.jiec.2018.11.041  Export Citation
Advances in dynamic microphysiological organ-on-a-chip: Design principle and its biomedical application
Sang Hun Lee, and Bong-Hyun Jun1, †
  • Department of Bioengineering, University of California Berkeley, 94720, CA, USA
  • 1Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwanjin-gu, Seoul 143-701, Republic of Korea
E-mail:
Recently, microfluidic organomimetic technology with precise spatiotemporal fluid control has offered unprecedented benefits to create physiologically-relevant in vitro organ models by recapitulating subtle organ-specific variations. The fundamental design principle of the microfluidic organ-on-a-chip (OoC) platform is founded on ‘reverse engineering’ living organs, which are deconstructed to recapitulate their essential function. In addition, OoC has leveraged recapitulation of multiorgan-level function with inter- connection and has modeled human pathophysiology. This review aims to highlight recent advances of the microphysiological dynamic OoC platform, exploring its biomedical and personalized medicine applications. We will discuss the critical aspects of OoC development and provide guidance to researchers to build physiologically-relevant OoCs in terms of cell source, perfusion flow, micro-sized biomimetic organ architecture, and mechanobiological motion. Finally, future directions for multi-OoCs are discussed along with the technical challenges encountered in drug development pipelines of the pharmaceutical industry.
Keywords:Organ-on-a-Chip (OoC);Microphysiological systems;Induced pluripotent stem cell;Dynamic perfusion flow;Biomimetic organ architecture;Mechanobiological motion;Multi organ-on-a-chip;Pharmacokinetic-pharmacodynamics;model
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