Cytoprotective effects and mechanisms of quercetin, quercitrin and avicularin isolated from Lespedeza cuneata G. Don against ROS-induced cellular damage

Keon Soo Lee; Soo Nam Park

Journal of Industrial and Engineering Chemistry, Vol.71, 160-166, March, 2019

DOI10.1016/j.jiec.2018.11.018 Export Citation

Cytoprotective effects and mechanisms of quercetin, quercitrin and avicularin isolated from Lespedeza cuneata G. Don against ROS-induced cellular damage

Keon Soo Lee, and Soo Nam Park^†

Department of Fine Chemistry, Cosmetic R&D Center, Cosmetic Industry Coupled Collaboration Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 01811, Republic of Korea

E-mail:

The purpose of this study was to compare the anti-oxidative and cytoprotective effects of quercitrin and avicularin isolated from Lespedeza cuneata G. Don extract to those of quercetin, an aglycone of quercitrin, and avicularin. Quercetin had higher antioxidative activity and cell penetration ratio than its glycosides, resulting in greater cytoprotective effects against 1O2. The cytoprotective effects against cell damage seems to reflect 1O2 quenching rate, free radical and ROS scavenging activity, and cell permeability. Among them, cell permeability to block free radical initiation and chain reactions in cell membranes is considered to be the most important feature of cytoprotective activity.

Keywords:Cytoprotective effect;Quercetin;Quercitrin;Avicularin;Antioxidant mechanism

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Seong JS, Xuan SH, Park SH, Lee KS, Park YM, Park SN, J. Microbiol. Biotechnol., 27, 1961 (2017)
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[1] Park SN, Kim MJ, Ha JH, Lee NH, Park JO, Lee JW, Kim DH, Yoo CS, J. Photochem. Photobiol. B-Biol., 164, 30 (2016)

[2] Valle LG, Biomed. Aging Pathol., 1, 1 (2011)

[3] Luceri C, Bigagli E, Femia AP, Caderni G, Giovannelli L, Lodovivi M, Toxicol. Rep., 5, 141 (2018)

[4] Yaar M, Gilchrest BA, Br. J. Dermatol., 157, 874 (2007)

[5] Park SN, J. Soc. Cosmet. Scientists Korea, 23, 75 (1997)

[6] Park SN, Korean J. Food Sci. Technol., 35, 510 (2003)

[7] Won DH, Han SB, Hwang JP, Kim SJ, Park JO, Park SN, J. Soc. Cosmet. Scientists Korea, 38, 297 (2012)

[8] Han SB, Gu HA, Kim SJ, Kim HJ, Kwon SS, Kim HS, Jeon SH, Hwang JP, Park SN, J. Soc. Cosmet. Scientists Korea, 39, 1 (2013)

[9] Kanofsky JR, Chem. Biol. Interact., 70, 1 (1989)

[10] Kanofsky JR, Hoogland H, Wever R, Weiss SJ, J. Biol. Chem., 263, 9692 (1988)

[11] Yano S, Hirohara S, Obata M, Hagiya Y, Oguro S, Ikeda A, Katoka H, Tanaka M, Joh T, J. Photochem. Photobiol. C, 12, 46 (2011)

[12] Circu ML, Aw TY, Free Radic. Biol. Med., 48, 749 (2010)

[13] Slater TF, Biochem. J., 222, 1 (1984)

[14] Xuan SH, Kim GY, Yu JY, Kim JW, Yang YR, Jeon YH, Jeong YJ, Kim AR, Park SN, Appl. Chem. Eng., 27(6), 620 (2016)

[15] Park SH, Shin HS, Lee NH, Hong IK, Park SN, Appl. Chem. Eng., 29(1), 49 (2018)

[16] Masaki H, Sakaki S, Atsumi T, Sakurai H, Biol. Pharm. Bull., 18, 162 (1995)

[17] Park SN, Lee TN, J. Soc. Cosmet. Scientists Korea, 10, 75 (1984)

[18] Park SN, Choi SW, Boo YC, J. Soc. Cosmet. Scientists Korea, 16, 1 (1990)

[19] Park SN, Appl. Chem. Eng., 14, 657 (2003)

[20] Seong JS, Xuan SH, Park SH, Lee KS, Park YM, Park SN, J. Microbiol. Biotechnol., 27, 1961 (2017)

[21] Lee HJ, Lim GN, Park MA, Park SN, Kor. J. Microbiol., 39, 63 (2011)

[22] Lee HJ, Gu HA, Park SN, Kor. J. Microbiol., 40, 237 (2012)

[23] Derosa MC, Crutchley RJ, Coord. Chem. Rev., 233, 351 (2002)

[24] Park SN, Won DH, Hwang JP, Han SB, J. Ind. Eng. Chem., 20(5), 3046 (2014)