Erroneous information from sensors affect process monitoring and control. An algorithm with multiple model identification methods will improve the sensitivity and accuracy of sensor fault detection and data reconciliation (SFD&DR). A novel SFD&DR algorithm with four types of models including outlier robust Kalman filter, locally weighted partial least squares, predictor-based subspace identification, and approximate linear dependency-based kernel recursive least squares is proposed. The residuals are further analyzed by artificial neural networks and a voting algorithm. The performance of the SFD&DR algorithm is illustrated by clinical data from artificial pancreas experiments with people with diabetes. The glucose-insulin metabolism has time-varying parameters and nonlinearities, providing a challenging system for fault detection and data reconciliation. Data from 17 clinical experiments collected over 896h were analyzed; the results indicate that the proposed SFD&DR algorithm is capable of detecting and diagnosing sensor faults and reconciling the erroneous sensor signals with better model-estimated values. (c) 2018 American Institute of Chemical Engineers AIChE J, 65: 629-639, 2019