The surface properties of catalyst supports are important in regulating the catalytic properties of heterogeneous catalysts. Herein, we studied the effect of acid-base properties of alumina on metal-support interaction and coke deposition, and investigated the stability of catalysts in propane dehydrogenation (PDH) using PtSn/Al2O3. We prepared gamma-Al2O3 (A750) from ammonium aluminum carbonate hydroxide (AACH) and compared it with a commercial sample (Sasol Puralox SBA-200; P200). We loaded 0.5 wt% Pt and 0.9 wt% Sn on alumina then conducted propane dehydrogenation at 590 degrees C (WHSV = 5.2 h(-1)). PtSn/A750 and PtSn/P200 showed compatible initial activity (conversion = (similar to)50%) and selectivity (> 95%). After 20 h of reaction, PtSn/A750 showed a slight decrease in activity (39.9%) while the activity of PtSn/P200 dropped significantly (28.4%). Spent catalysts showed different metal sintering behavior and coke deposition which are well known causes for catalyst deactivation. A high strength of Lewis acid sites in A750 (higher T-d in ethanol TPD) prevented the sintering of metal by strong metal-support interaction. Also, the lower number of Lewis acid sites in A750 than that of P200 reduced deposited coke on the catalysts (PtSn/A750: 1.8 wt% and PtSn/P200: 8.6 wt%). Furthermore, diffuse reflectance infrared Fourier-transform spectroscopy after CO adsorption at -150 degrees C clearly demonstrated that coke deposition was initiated from Lewis acid sites on the alumina surface, but then aromatization occurs at these sites. These results suggested that strong metal-support interactions to hold metal particles and less residual Lewis acid sites after metal loading to reduce coke deposition are important factors for designing stable and coke-resistant PtSn on alumina catalysts. Furthermore, precise characterization and understanding of the acid-base properties of alumina will contribute in developing catalysts with high stability.