In this work, Pt nanoparticles were electrodeposited through cyclic voltammetry technique on three dimensional nanoporous gold prepared from Au-based metallic glass precursor by chemical de-alloying. The electro-catalytic properties of the as-prepared samples were tested through potential cycling towards methanol oxidation in alkaline solution. Current density plots vs scan numbers indicate that the electrodes are active for the electro-oxidation of methanol and the Pt nanoparticles electrodeposited on gold ligaments contribute to increasing catalytic properties. In particular, results indicate that nanoporous gold with 30 cycles of Pt electrodeposition exhibits competitive higher activity and longer durability towards methanol electro-oxidation.