In this work, we studied indium fin oxides (ITOs) modified with dendrimer-encapsulated N nanoparticles (pt DENs) to develop efficient p-aminophenol (p-AP) redox cycling platforms. The ITO surfaces were modified via electro-oxidative grafting of the terminal amine groups of the dendrimers encapsulating catalytic pt nano-particles (Le., pt DENs). Compared to conventional ITO surfaces, the pt DEN-modified ITOs showed highly enhanced electrochemical oxidation current of p-AP even at low potentials with no significant background oxidation current due to the catalytic activity of pt nanoparticles, leading to high signal-to-background ratio for sensitive p-AP redox cycling. The enhanced p-AP redox cycling on the pt DEN-modified ITOs led to similar to 17.8 times higher sensitivity of the p-AP redox cycling than that obtained with conventional ITOs. In addition, the pt DEN-modified ITOs were found to be suitable as platforms for the immobilization of oligonucleotides due to the globular structure of dendrimers, which have a high surface-to-volume ratio and multiple terminal functional groups, grafted on ITO surfaces. The DEN-modified ITOs could be further functionalized by the immobilization of single-strand DNA oligonucleotides with high surface density (ie., (2.2 +/- 0.4) x 10(12) molecules/cm(2)), which is similar to 4.4-fold higher than that on the surface of conventional ITOs.