Two-component solvent-born polyurethane coatings for the protection of bronze from corrosion were prepared. Trisilanol-heptaisooctyl polyhedral oligomeric silsesquixane (POSS) nanoparticles were exploited to increase the coating protective efficiency. Its improvement was confirmed through a combination of characterisation techniques. In particular, the POSS addition caused an increase of the water contact angle, and an enhancement of the elastic connotation and abrasion resistance of the polyurethane coating. Potentiodynamic polarisation measurements also indicated that the coating containing POSS nanoparticles has an improved protection efficiency. Impedance spectroscopy revealed that the magnitude of low-frequency impedance of polyurethane coatings decreased more for the coating without POSS during exposure in electrolyte for thirty days. Ex situ IR reflection-absorption spectroelectrochemistry was exploited to get insight into the degradation of coatings during chronocoulometric charging at anodic potentials. IR reflection-absorption technique was also used to evaluate any possible effect of different stripper solutions on the bronze substrate.