Glioblastoma (GBM) is one of the major cause of the cancer-related fatality worldwide. Several circular RNAs (circRNAs) have been observed to exert functions in GBM. The current study is aimed to explore the potential mechanism of circ_0074027 via miR-518a-5p and IL17RD in GBM progression. Circ_0074027 expression was determined in a cohort of 50 pairs of GBM specimens and five cell lines by qRT-PCR. In addition, the association between circ_0074027 expression and its clinical value was analyzed by Fisher's exact test. Cell growth, clone formation, apoptosis, migration and invasion was evaluated after over express or knockdown the expression of circ_0074027 in GBM cells. Dual luciferase reporter assays were conducted to evaluate the relevant intermolecular target relationships. Circ_0074027 expression was evidently upregulated in GBM tissue specimens and cells compared to the adjacent non-tumorous tissues and NHA, respectively. The upregulation of circ_0074027 is related to clinical severity and exerts oncogenic functions in GBM. Moreover, circ_0074027 could sponge miR-518a-5p to release its suppression on IL17RD. Our findings provide evidence that circ_0074027 plays an oncogenic role in GBM by regulating miR-518a-5p/IL17RD signaling. (C) 2019 Elsevier Inc. All rights reserved.