In this study, fate of antibiotic resistance genes (ARGs - lmrA, lmrB, ermB, lnuA, lnuB and vgaC) and species distribution of heavy metals during lincomycin mycelial residues hydrothermal treatment (HT) process were investigated. The results showed that HT could reduce both ARGs and mobile genetic elements effectively by 1.02 to 4.14 logs. Total bacterial biomass reflecting by 16S rRNA decreased from 1.27x10(9) to 4.47x10(5) copies g(-1) dry weight. Moreover, half-lives of these targets varied from 2.4 min (ermB) to 8.9 min (lmrB) in the first 30 min of treatment based on a biphasic first-order kinetic model. After the first 30 min, however, half-lives ranged between 15.4 min (lmrA) and 247.6 min (ISCR1). Complexation and precipitation resulted in the transformation of heavy metals from weakly bounded to relatively stable fraction in HT process. Simultaneously, their environmental risk level decreased by at least one grade.