A novel bifunctional periodic mesoporous organosilica supported isatin-Schiff-base/manganese complex [BPMO@ISB/Mn(II)] is prepared, characterized and its catalytic performance is investigated in the synthesis of dihydropyrano[3,2-c]chromene derivatives. The BPMO@ISB was prepared via grafting of 3-aminopropyltrimethoxysilane (APTS) on a phenylene based PMO followed by treatment with isatin. The BPMO@ISB was then reacted with Mn(NO3)(2)4H(2)O to afford the BPMO@ISB/Mn(II) nanocatalyst. This catalyst was characterized using Fourier transform infrared (FT-IR) spectroscopy, thermal gravimetric analysis (TGA), energy-dispersive X-ray (EDX) spectroscopy, scanning electron microscopy (SEM), low angle powder X-ray diffraction (LAPXRD) analysis and transmission electron microscopy (TEM). The BPMO@ISB/Mn(II) nanocatalyst was successfully used in one-pot synthesis of 3,4-dihydropyrano[c]chromene derivatives at room temperature. In addition, the stability, recyclability and reusability of designed nanocatalyst were studied under applied conditions. [GRAPHICS] .