The high-sulfur gas sweetening process is energy consuming. To analyze its energy efficiency effectively, and look for ways to improve this process, a novel energy-efficiency evaluation method based on the yield-energy-selectivity and efficiency coefficient methods was proposed. First, the yield, energy, and selectivity are selected as evaluation indicators to establish the yield-energy-selectivity evaluation model. Then, the coefficient and score of each indicator were determined by using the analytical hierarchy process and efficacy coefficient method, respectively. Finally, the proposed energy-efficiency evaluation method was applied to the actual high-sulfur gas sweetening process. The evaluation results were in good agreement with those obtained by actual experiences.