A combined system of polyvinylpyrrolidone (PVP) and nanoscale zerovalent iron (NZVI) with copper (Cu) bimetallic particles (PVP-NZVI/Cu) was designed for ciprofloxacin (CIP) reduction under weak magnetic field (WMF) condition. The surface morphology and physicochemical properties of the novel catalytic materials were further characterized. In addition, the catalytic reactivity of PVP-NZVI/Cu was determined in the presence or absence of WMF. Experimental results demonstrated that the catalytic performance of PVP-NZVI/Cu system was enhanced by the introduction of WMF with maximum removal rate of CIP reaching 95.6% (120 min). Kinetic analysis exhibited that the degradation of CIP in compliance with pseudo-first-order kinetics. Eventually, the degradation products of CIP after reacting with the PVP-NZVI/Cu nanocomposites were determined by the mass spectrometry (MS). Quantitative analysis of PVP-NZVI/Cu adsorption and Fenton oxidation during the CIP removal process were also evaluated. The roles of PVP-NZVI/Cu adsorption/Fenton oxidation were dynamically changed and the Fenton oxidation was observed to be greatly strengthened as the removal process proceeded. The study provided a new insight into the removal of CIP by NZVI, which has prospect for the practical application of NZVI.