Increasing demands for electrochemical glucose sensors with high overall performance have recently attracted intensive attention. Herein, we report a novel sandwich- like nanoarchitecture composed of uniform CuO nanowire array layers grown on the nanoporous Cu2O film, which was synthesized via annealing the nanoporous copper thin film obtained by dealloying Cu-based metallic glass precursors. The glucose sensor based on the newly developed CuO/Cu2O nanocomposite exhibits prominent overall electrocatalytic performance towards the oxidation of glucose with a wide linear dynamic detection range from 0.1 to 6mM, high sensitivity up to 1.95 mA/cm(2) mM, fast response time of less than 1.5 s, low detection limit of 1 mM(S/N = 3) as well as excellent selectivity. The enhanced electrocatalytic property of the nanocomposite is attributed to the high surface area originating from the in-situ grown CuO nanowire array structure and synergetic bi-continuous nanoporous Cu2O substrate. This finding not only provides promising candidates for blood glucose sensing, but also opens a new avenue to designing nanostructured catalysts for engineering applications in general. (C) 2019 Elsevier Ltd. All rights reserved.