The objective of this paper is the investigation of a thermal photovoltaic concentrating collector operating with and without nanofluids. The use of nanofluid Syltherm 800/copper oxide with 5% volumetric concentration is examined and it is compared with the base fluid. The examined thermal photovoltaic has a parabolic concentrator and an inverted flat insulated receiver. The analysis is conducted with SolidWorks Flow Simulation which is able to perform the thermal, optical and flow analysis. According to the present study, the system is able to operate for inlet fluid temperatures up to 200 degrees C which is a promising result. Moreover, it is found that the use of nanofluid leads to enhancement both in thermal and electrical performance for all the examined cases (different combinations of flow rates and inlet temperatures). For an inlet temperature at 100 degrees C and flow rate 540 L/h with nanofluid, the thermal efficiency and the electrical efficiency were found at 46.84% and 6.60% respectively. For this case, the enhancements in the thermal, electrical, total and exergy efficiencies were found at 1.66%, 5.17%, 2.08% and 3.05% respectively.