This paper is concerned with the regional stabilization problem for discrete time-delay systems with actuator saturations. Different from some existing delay-independent techniques handling the saturation nonlinearity, a delay-dependent polytopic approach is first proposed in a discrete-time framework. Then, by combining with an augmented Lyapunov function, a discrete Wirtinger-based inequality and some novel analysis techniques, improved delay-dependent regional stabilization conditions are established by means of linear matrix inequalities. Finally, it is shown via two numerical examples that the obtained results are less conservative than some existing ones yet providing a larger estimate of an initial condition set.