This paper presents a small-gain result for large-scale interconnected systems composed of hybrid subsystems. It is assumed that the subsystems are input-to-output practically stable (IOpS) with offset and unboundedness observability (UO), and the interconnected system can be proved to be IOpS with offset and UO as long as the proposed small-gain condition is satisfied. If, moreover, the assumption of IOpS on the subsystems is reduced to input-to-output stability (IOS), then the interconnected system is IOS.