A modified model of bubble point pressure for binary mixtures based on the simplified Wilson equation was proposed to study the homogeneous nucleation of binary fuel mixture. The model was verified for four binary systems and well agreed with the available experimental results. On the basis of the bubble point pressure model, the mole fraction of each component in the vapor phase was obtained. The homogeneous nucleation model combined with the classical nucleation theory and the bubble point pressure model was used to predict the critical bubble radius and the nucleation rate of dimethyl ether (DME)/n-decane and DME/n-dodecane binary systems. The influence of blending ratio on homogeneous nucleation was discussed under several ambient pressures. The superheat limit temperature (SLT) was also calculated for the tested binary systems. The results showed that even a small amount of light component could obviously reduce the temperature needed to trigger the homogeneous nucleation. Consequently, the intensities of homogeneous nucleation and flash boiling could be also greatly improved. The calculation revealed that depressurization could promote the performance of homogeneous nucleation and flash boiling of the binary mixtures. (C) 2018 Elsevier Ltd. All rights reserved.