A commercial laccase, Suberase (R) from Novozymes, catalyses the synthesis of triaminated cyclohexa-2,4-dienones and a methylbenzene-1,2-diol derivative. The primary amine (analine) and the catechol was reacted under mild conditions (40 degrees C) in a reaction vessel open to air in the presence of Suberase (R) and a co-solvent (DMF) at pH 6.0. This reaction was also conducted using an environmentally friendly co solvent (EtOH). Triamination is favoured over diamination and monoamination. (C) 2018 Elsevier Inc. All rights reserved.