The solubility of gatifloxacin in 12 pure organic solvents (methanol, ethanol, n-propanol, n-butanol, isopropanol, acetone, butanone, acetonitrile, 1,4-dioxane, ethyl acetate, toluene, and N,N-dimethylformamide (DMF)) was obtained at temperatures from 273.15 K to 318.15 K. The results show that the solubility of gatifloxacin in those 12 pure solvents increases with increasing temperature. At a given temperature range, they gradually decrease in the following order: ethyl acetate (6.789 x 10(-3), 298.15 > DMF (5.657 X 10(-3), 298.15 > butanone (3.488 x 10(-3), 298.15 > acetonitrile (2.811 X 10(-3), 298.15 > n-butanol (2.246 x 10(-3), 298.15 K) > acetone (1.766 X 10(-3), 298.15 K) > 1,4-dioxane (1.288 X 10(-3), 298.15 K) > n-propanol (0.922 x 10(-3), 298.15 K) > ethanol (0.698 X 10(-3), 298.15 > methanol (0.531 X 10(-3), 298.15 K) > isopropanol (0.401 x 10(-3), 298.15 K) > toluene (0.261 X 10(-3), 298.15 K). The (KAT-LSER) model was applied to analyze the effect of the solute-solvent intermolecular interactions on the solubility in those pure solvents. Moreover, the obtained solubility data were correlated with the modified Apelblat equation and the lambda h equation. Between the experimental and calculated solubility data, the largest value of relative average deviations (RAD) was 0.77 X 10(-2), and it is 0.15 X 10(-4) for root mean-square deviations (RMSDs). The results showed that the experimental values are in good agreement with the calculated values. The experimental solubility and the models in this study could be helpful in applications in the field of medicine.