The determination of 2-amino-6-chloropurine solubility in water and 11 organic solvents including dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), 2-butanone, ethylene glycol (EG), n-butanol, n-propanol, isobutanol, isopropanol, 1,4-dioxane, ethanol, and methanol was performed by using the shake flask technique. The experiments were conducted covering the temperatures from 278.15 to 333.15 K at ambient pressure p = 101.2 kPa. The values of solubility for 2-amino-6-chloropurine in selected solvents increased as the temperature rised. The maximum solubility value of 2-amino-6-chloropurine was recorded in DMSO, and the minimum, in water. They ranked as DMSO > DMF > 2-butanone > EG > n-butanol > n-propanol > isobutanol > isopropanol > 1,4-dioxane > ethanol > methanol > water. The solubility data obtained were mathematically described through the Apelblat equation. The largest percentage of average relative deviation was 1.75 X 10(-2), and the maximum value of root-mean-square deviation, 1.14 X 10(-4). Moreover, using the Kamlet and Taft linear solvation energy relationship analysis of the solvent effect, the type and degree of soleent, solute, and solvent-solvent interactions were recognized.