In commonly used solvents, the dissolving capacity of temozolomide is limited. This work is to research the dissolution behavior in different polarity ranges. The solubility of temozolomide in methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, N,N-dimethylformamide (DMF), ethyl acetate, dimethyl sulfoxide (DMSO), 1,4-dioxane and mixture of (DMF + ethanol) was experimentally determined at T= 293.15-333.15 K. The modified Apelblat equation, lambda h equation, Jouyban-Acree model and CNIBS/R-K model are applied to correlate the solubility. All the values of RAD and RMSD are no more than 3.43 x 10(2) and 2.86 x 10(4), respectively. Apparent thermodynamic analysis indicate that the dissolution is an endothermic, spontaneous and entropy driven process. More importantly, the change of temperature and the addition of co-solvent (DMF) can make the operation of crystallization purification more controllable. (C) 2018 Published by Elsevier Ltd.