Drug combination therapy is an emerging technology to treat the diseases which are still annoyance to human being. Combination of two or more drugs can deal with diseases in a better way. Various different techniques have been introduced which can deliver combination of drugs in a safe and more controlled manner. In our research, we prepared polyphosphazene-based blend microspheres which can deliver two different drugs in a much sustained manner for long time. Acetamidophenol, commonly used drug, was attached to the polyphosphazene main chain to produce drug-polymer conjugates, and these were then blended with PMMA in different ratios to fabricate the microspheres of variable and controlled size. Another anticancer drug camptothecin was loaded in these microspheres to fabricate dual-drug-loaded microsphere. Furthermore, in vitro drug release behaviors of fabricated microspheres were also demonstrated.