Plasmonic nanoparticles can strongly interact with adjacent photosensitizer molecules, resulting in a significant alteration of their singlet oxygen (O-1(2)) production. In this work, we report the next generation of metal-enhanced O-1(2) nanoplatforms exploiting the lightning rod effect, or plasmon hot spots, in anisotropic (nonspherical) metal nanoparticles. We describe the synthesis of Rose Bengal-decorated silica-coated silver nanocubes (Ag@SiO2-RB NCs) with silica shell thicknesses ranging from 5 to 50 nm based on an optimized protocol yielding highly homogeneous Ag NCs. Steady-state and time resolved O-1(2) measurements demonstrate not only the silica shell thickness dependence on the metal-enhanced O-1(2) production phenomenon but also the superiority of this next generation of nanoplatforms. A maximum enhancement of O-1(2) of approximately 12-fold is observed with a 10 nm silica shell, which is among the largest O-1(2) production metal enhancement factors ever reported for a colloidal suspension of nanoparticles. Finally, the Ag@SiO2-RB NCs were benchmarked against the Ag@SiO2-RB nanospheres previously reported by our group, and the superior O-1(2) production of Ag@SiO2-RB NCs resulted in improved antimicrobial activities in photodynamic inactivation experiments using both Gram-positive and-negative bacteria model strains.